Proton Pump Inhibitors Accelerate Endothelial Senescence

Proton Pump Inhibitors Accelerate Endothelial Senescence.

RATIONALE Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, which are now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal, and neurological morbidity. OBJECTIVE To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in...

Letter by Marlicz et al Regarding Article, “Proton Pump Inhibitors Accelerate Endothelial Senescence”

Letter by Marlicz et al Regarding Article, “Proton Pump Inhibitors Accelerate Endothelial Senescence” We read with great interest the study by Yepuri et al on the effects of proton pump inhibitors (PPIs) on endothelial cells. The investigators exposed human microvascular endothelial cells to PPIs and observed reduced cell proliferation, a decrease in NO, and impaired proteostasis. Moreover, num...

Letter by Marlicz et al Regarding Article, "Proton Pump Inhibitors Accelerate Endothelial Senescence".

Letter by Marlicz et al Regarding Article, “Proton Pump Inhibitors Accelerate Endothelial Senescence” We read with great interest the study by Yepuri et al on the effects of proton pump inhibitors (PPIs) on endothelial cells. The investigators exposed human microvascular endothelial cells to PPIs and observed reduced cell proliferation, a decrease in NO, and impaired proteostasis. Moreover, num...

Proton Pump Inhibitors: Omeprazole

Oral Proton Pump Inhibitors

There is currently a lack of evidence to suggest superior clinical efficacy of one oral proton pump inhibitor over any other. Proton pump inhibitors display similar doseresponse relationships with similar potencies and efficacies at the equivalent dose. The decision to select one proton pump inhibitor over another is likely to be based on the agents’ licensed indication, patient tolerability an...